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Information × Registration Number 0212U005856, 0112U004108 , R & D reports Title Research of physico-chemical properties and bioactivity of synthetic macrocyclic nanoobjects and their functionalyzed derivatives towards the therapeutically important protein targets in vitro popup.stage_title Head Vovk A., Registration Date 26-12-2012 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 It is established, that inhibiting action of the some of bis- and tetrakis-substituted macrocycles on activity of РТР1В is described by inhibition constants in the micromolar range. On example of derivatives bis-ketophosphonic and bis-?-hydroxymethylphosphonic acids the selectivity of РТР1В inhibition was established in comparison with ТС-РТР, SHP-2, CD45. Kinetic features of slow binding of the phosphorylated macrocyclic compounds are found out and modelling of enzyme-inhibitor complexes was carried out by using molecular docking calculations.5481 Product Description popup.authors І.М. Міщенко В.Ю. Танчук О.В.Музичка popup.nrat_date 2020-04-02 Close