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Information × Registration Number 0212U005918, 0112U007291 , R & D reports Title Study of biocompatibility and molecular mechanisms of action of fulleren-based novel drug delivery systems towards tumor cells popup.stage_title Head Panchuk Rostyslav Ruslanovych, Registration Date 04-01-2013 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 It is shown that fulleren-doxorubicin complexes kill tumor cells with 3-fold higher efficiency compared to native doxorubicin. This phenomena is also accompanied by more intensive induction of apoptosis in tumor cells. Strengthening of anticancer effect of doxorubicin by its immobilization on fullerenes can be explained by speed-up of induction of oxidative stress by this drug in target cells which is mediated by superoxide radicals, as shown by means of flow cytometry and and fluorescent microscopy. These results can help to to decrease the therapeutic doses of anticancer drugs during cancer chemotherapy with preserving of her high efficiency, and thus to improve a prognosis of cancer treatment. The achieved results were published in 1 article and 3 conference thesis Product Description popup.authors Панчук Ростислав Русланович popup.nrat_date 2020-04-02 Close