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Information × Registration Number 0212U006399, 0110U003761 , R & D reports Title Receptor-dependent mechanisms of urokinase action popup.stage_title Head Drobot Lyudmyla Borysivna, Registration Date 28-03-2012 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 The plasmid construct for overexpression of urokinase receptor (uPAR) in mammalian cells and polyclonal antibodies to PAI-1 were obtained. It was shown increased production of urokinase system components uPA, uPAR and РАІ-1 in sublines of human breast adenocarcinoma cells MCF-7 with stable overexpression of adaptor protein Ruk/CIN85. It was demonstrated that stimulation of PAI-1 expression under the action of Ruk/CIN85 depends on hypoxia response site in PAI-1 gene promoter. The ability of urokinase to change the effects of epidermal growth factor (EGF) on the activation of Erk1/2 kinase depending on Ruk/CIN85 expression and to impair the EGF stimulating effects on cell migration and proliferation were revealed. Product Description popup.authors 2. Самойленко Анатолій Анатолійович 6.Грищенко Оксана Володимирівна Биць Надія Вікторівна Козлова Ніна Володимирівна Марченко Світлана Миколаївна popup.nrat_date 2020-04-02 Close