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Information × Registration Number 0212U006425, 0109U000945 , R & D reports Title The invesigation of structure and properties of the reduced porphyrins with meso-quinolinyl substituents popup.stage_title Head Galkin Boris Mikolayovich, Registration Date 28-03-2012 Organization Odesa I.I.Mechnikov national university.Pervomaisk institute. popup.description2 Object of study - porphyrin compounds with isomeric meso-quinolinyl substituents, their functional derivatives and metal complexes, reduced and quaternarnized derivatives of these compounds. Purpose - to the structural and functional study of partially reduced porphyrin compounds based on synthetic meso-substituted porphyrins as potential sensitizers for photodynamic inactivation of harmful microorganisms. The main hypothesis of work - is to assume that the bulk condensed heterocyclic meso-substituents in the porphyrin macrocycle will favor the stability of the partially reduced forms of the macrocycle and the compounds have improved photophysical characteristics, the use of the latter as prospective sensitizers for photodynamic inactivation. For the first time carried out a systematic study of methods for the partial reduction of the isomeric meso-substituted quinolinylporphyrins. Is proved, that the recovery of isomeric quinolinylporphyrins to bacteriochlorin is best carried out in a solvent mixture of pyridine-methanol under the action of diimide, which is formed by oxidation of hydrazine hydrate with sodium periodate (NaIO4). Clarified the concept of reduction of a number of metal complexes of quinolinylporphyrins to the corresponding chlorins and bacteriochlorins and theoretically proved the possibility of synthesis of isomeric quinolinylbacteriochlorin. It is proved that the nature of the metal in the metal complex of the isomeric meso-substituted quinolinylporphyrins are very strong effect on the reduction of the double bonds on the periphery of the macrocycle, but none of the studies of metals (Cu, Ni, Zn) should not be used for synthesis of bacteriochlorin derivatives - bacteriochlorins best yields were obtained just for the free bases quinolinilporphyrins. For the first time carried out a systematic study of photodynamic inactivation of conditional patogenic microorganisms such as Staphylococcus aureus, Salmonella enteritidis and Pseudomonas aeruginosa through partially reduced isomers quinolinylporphyrins, their metal complexes and functional derivatives. The investigated compounds were also a significant effect on the photoinduced representatives of yeast-like fungi Candida albicans and Cryptococcus albidus. The investigated compounds were also the ability to inhibit the formation of Pseudomonas aeruginosa biofilms under the condition of irradiation with visible light. The concept of using partially reduced quinoolinylporphyrins of defined structure more efficiently as photosensitizers for photodynamic inactivation of pathogenic bacteria that are resistant to known antibiotics was grounded. Product Description popup.authors Ішков Юрій Васильович Водзінський Сергій Валентинович Кириченко Ганна Михайлівна Філіпова Тетяна Олегівна popup.nrat_date 2020-04-02 Close