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Information × Registration Number 0212U006709, 0109U006245 , R & D reports Title Creation of multilayer polyelectrolyte microcapsules for controlled delivery of low-molecular drugs popup.stage_title Head Guzenko N.V., Registration Date 18-06-2012 Organization Institute of Surface Chemistry of the National Academy of Sciences of Ukraine popup.description2 Found that in water forming a multilayer film due to formation of polyelectrolyte complexes for the case of polymer pairs poliheksametylenhuanidyn-hydrochloride (PHMG-GC) and sodium carboxymethylcellulose (Na-CMC) is possible at pH ? 6. This allows you to adjust the permeability of the walls of a multilayer polymer film by lowering the pH. Methods of optical microscopy and thermogravimetric analysis shows that the formation of multilayer coatings by speech turn adsorption of oppositely charged polyelectrolytes on the surface of the carbonate matrix is observed only for the polymer pair CMC-PHMG. In the case of PSS-polymer pair PHMG is pushing pre-sorbed over the states with the surface of CaCO3 in a solution of oppositely charged polyelectrolytes. The method of the speech turn 20 adsorption layers of oppositely charged polyelectrolytes on the surface of synthesized carbonate matrix formed polymer shell with a total thickness of about 5 microns, a weight was 13.6% of the mass of the nucleus. It is shown that during the formation of polyelectrolyte shell is polymorphic transformation of calcium carbonate, which leads to reduction of vaterytu. After application of 10 double layers PHMG GC and Na-CMC calcium carbonate cores represented only polymorphic modifications of calcite. The calculated density of the polyelectrolyte shell, which was about 4 ? 104 g/m3, indicating the formation of loose strongly hydrated film in the synthesis of the polymer complex. Following dissolution of inorganic matrix with a solution of sodium etylendyamintetraotstovoyi acid (EDTA) allowed to obtain hollow capsules are stable in neutral medium. Product Description popup.authors Габчак О.Л. Гузенко Н.В. Телегеєв І.Г. popup.nrat_date 2020-04-02 Close