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Information × Registration Number 0212U006990, 0112U006062 , R & D reports Title The development of new approaches to the synthesis of medium azacycles annulated with aryl (hetaryl) fragment popup.stage_title Head Tolkunov Sergey Volodimir, Registration Date 06-11-2012 Organization The L.M.Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry popup.description2 The methods of synthesis of benzofuropyridines, benzothienopyridines, furopyridines, thienopyridines was developed by cyclization heterylethylamines. The reaction of Picte-Spenglera is thoroughly studied in benzothienyl- and benzofurylethylamines row. The optimum terms of synthesis of 1-phenyl-2-methyl-1,2,3,4-tetrahydrobenzothienopyridines and 1-phenyl-2-methyl-1,2,3,4-tetrahydrobenzofuropyridines are found and work of necessary amounts is carried out for the study of their reactions with the activated alkynes. The new type of catalyst agent in Picte-Spengler reaction is offered, which allows to get necessary hetarylpyridines with high yield and cleanness. Unusual passing of Eshwayler-Clark reaction among 1-phenyl-2-methyl-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridines was discovered, which passing with dearylated of 1-aryl substitute. The general method of construction 1-(2-carboxyphenyl)benzothieno[2,3-c]pyridines is offered by domino reactions, passing at the cyclization of 2-(3-oxo-4-phenylmercaptobutyl)-1,3-isoindolindiones in polyphosphoric acid. The new variant of domino reactions of tetrahydrobenzofuro[2,3-c]pyridines with dimetylacetylendicarboxylate or metylpropiolate is found which results in spirobenzofuranes. Product Description popup.authors Єреско Олександр Борисович Земська Євгенія Олексіївна Тамаркина Юлія Володимировна Толкунов Валерій Сергійович Толкунов Сергій Володимирович popup.nrat_date 2020-04-02 Close