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Information × Registration Number 0212U007067, 0110U006128 , R & D reports Title Development of fundamentals of cell therapy of heart pathologies popup.stage_title Head Lyubov L. Lukash, Доктор біологічних наук Registration Date 27-04-2012 Organization Institute of Molecular Biology and Genetics popup.description2 According to preliminary data among prohenotypovanyh (27 individuals) mice, there were animals with deletion of the gene b-kateninu among males and among females. We can assume that the deletion of the gene b-kateninu in myocardial tissue even in early embryogenesis is not compatible with life, this assumption is consistent with previous results where the observed low fertility of animals deletovanym gene b-kateninu. But keep in mind that the sample of 27 individuals is not representative, so this assumption needs further verification. Among the animals heterozygous for the gene deletovanym observed that females aged 1 month with this genotype (b-cat flox / wt; Cre +) reported twice the rate of the processed sample of our animals. It should be noted that the number of animals deficient for b-kateninom among males was lower than that by splitting Mendelivskoho genes: 16.6% males and for 25% while the frequency of females deficient for investigational gene was 26.6%. Pre can also be noted that the frequency of mutant genotype (b-cat flox / wt; Cre +) among females aged 1 month higher than among males Product Description popup.authors Бобик Василь Васильович Костецький Ігор Євгенович Мацевич Лариса Леонідівна Півень Оксана Олександрівна Сидорик Людмила Леонідівна popup.nrat_date 2020-04-02 Close