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Information × Registration Number 0212U007068, 0110U006128 , R & D reports Title Development of fundamentals of cell therapy of heart pathologies popup.stage_title Head Lyubov L. Lukash, Доктор біологічних наук Registration Date 27-04-2012 Organization Institute of Molecular Biology and Genetics popup.description2 Using umovnonokautnyh and transgenic animals show values ??between cell adhesion proteins - b-kateninu pislyanatalnomu in developing and shaping miokradu. It was found that complete loss of this protein is lethal in late embryogenesis or early pislyanatalnomu period. Animals with partial loss of gene b-kateninu, ie, deletion of only one allele did not differ morphologically from control animals, but observed a decrease with age index value in heart weight to body weight, or disability of physiological development mokardu with this mutation. Also, we have shown and increase protein expression plakohlobinu (g-kateninu). As evidence of its involvement in establishing and maintaining the structural integrity of the myocardium under deletion of one allele b-kateninu. Furthermore we show that protein deficiency b-kateninu in adult tissue infarction is stressful for the body, and possibly may cause the development of inflammatory processes and diseases attack Product Description popup.authors Бобик Василь Васильович Костецький Ігор Євгенович Мацевич Лариса Леонідівна Півень Оксана Олександрівна Сидорик Людмила Леонідівна popup.nrat_date 2020-04-02 Close