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Information × Registration Number 0212U007389, 0110U006192 , R & D reports Title Development of new approaches to combinational cancer enzymotherapy based on amino acids deprivation popup.stage_title Head Stasyk Oleh Volodymyrovych, Кандидат біологічних наук Registration Date 25-12-2012 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 The third stage is shown that starvation for arginine induces rapid autophagic response in human ovarian carcinoma cells SKOV3. Blocking the expression of a key protein of early stage of autophagy Beclin 1 led to cell death of SKOV3 during starvation for arginine, so it is likely that autophagy is a key factor of SKOV3 cell survival under conditions of arginine deficiency. It was revealed that the action of the autophagy inhibitor chloroquine on a background of arginine starvation prevents subsequent recovery of cell growth. Used cell line can serve as a convenient model for studies of signaling mechanisms involved in the regulation of process of autophagy with individual amino acids. Product Description popup.authors Барська Марина Леонідівна Бобак Ярослав Петрович Вовк Олена Іванівна Стасик Олег Володимирович Шуваєва Галина Юріївна popup.nrat_date 2020-04-02 Close