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Information × Registration Number 0212U008215, 0107U003343 , R & D reports Title Functional characterization of genes assiciated with initiation and progression of human brain glial and connective tissue tumours popup.stage_title Head Kavsan Vadym M, Registration Date 04-12-2012 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 Aim of the work is identification and chracterization of the genes differentialle expressed in glial and meningothelial tumors and normal human brain. 44 genes expressed in glioblastoma at sufficiently increased level were identified by SAGE. Increased expression levels of CHI3L1 and CHI3L2 genes can serve as new molecular markers of glial tumors. It was revealed that CHI3L1 activates ERK1/ERK2 phosphorylation thus initiated MAPK-signaling cascade. It was shown the influence of CHI3L2 and CHI3L1 on the duration of cellular MAPK-signaling and translocation pf phosphorylated ERK1/2 into nucleus. According to the results of the in vitro and in vivo investigations, CHI3L1 is a real oncoprotein which converts immortlized 293 cells into malignanly transformed cells. Gene expression signature of the glioblastoma was obtained and successfully applied for the clasterization of ther astrocytic gliomas of malignancy grades I-IV using Kohonen self-organizing maps (SOM). Product Description popup.authors Єршов Антон Вікторович Арешков Павло Олександрович Балинська Олена Вікторівна Бойко Оксана Іванівна Букреєва Тетяна Василівна Дмитренко Володимир Володимирович Кавсан Вадим Мусійович Чаусовский Тімур Йосипович Шостак Катерина Олександрівна popup.nrat_date 2020-04-02 Close