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Information × Registration Number 0212U008477, 0111U002249 , R & D reports Title Creating a pharmacologically active derivatives of pyridine, quinoline, isoquinoline, naftiridina, indolizine and their partially hydrogenated analogues popup.stage_title Head Dyachenko Vlаdimir Danilovich, Registration Date 17-12-2012 Organization Luhansk Taras Shevchenko National University popup.description2 The object of the study is functionalized derivatives of pyridine, isoquinoline, naphthyridine, indolizine and their partially hydrogenated analogs. The purpose of the project is development of methods for the synthesis of pyridine, isoquinoline, naphthyridine, indolizine derivatives and partially hydrogenated analogues and study of their biological activity. Methods: organic synthesis, IR, NMR 1H, NMR 13C and mass spectroscopy, elemental analysis and X-ray diffraction. Multicomponent condensation of aldehydes with CH-acids, amines and alkylating reagents was studied for the first time. Moreover this reaction results into acid cleavage benzoyiltrifluoracetone, which leads to the formation of 4,6-diaryl-2-thioxo-1,2-dihydropyridine-3-carbonitriles. The interaction of enamins 2-acilcycloalkanones with monothiodiamides of malonic acid was investigated for the first time within SNVin reaction, which helped synthesize biologically active partially hydrogenated hexahydro-izoquinolines. [3,3]-sigmatropic thio-Claisen rearrangement in series 2-propargylthio-1,4,5,6,7,8-hexahydroquinalines to 3-allenyl-2-thioxo-1,2,3,4,5,6,7,8-octahydroquinolines was synthesized for the first time. The research results can be used in organic synthesis laboratories at the Institute of Organic Chemistry NAS of Ukraine, the National Pharmaceutical University of Ukraine and the pharmaceutical industry to create the basic structures of drugs. They also can be used at chemical departments of universities to develop curricula of organic chemistry for postgraduates and graduate students. The branch use is chemistry and pharmacy.Key words: PYRIDINE, ISOQUINOLINE, NAPHTHYRIDINE, INDOLIZINE, ALKYLATION, REACTION SNVIN, CH-ACID, CONDENSATION, BIOLOGICAL ACTIVITY, [3,3]-SIGMATROPIC THIO- CLAISEN REARRANGEMENT. Product Description popup.authors Демчак Іван Валерійович Дяченко Іван Володимирович Карпов Євген Миколайович Красніков Денис Олександрович Нікішин Олександр Олександрович Пономаренко Дмитро Олексійович Рильська Тетяна Анатолііївна Феськов Ілля Андрійович Хорошилов Геннадій Євгенович popup.nrat_date 2020-04-02 Close