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Information × Registration Number 0212U008614, 0110U006268 , R & D reports Title Termo TRP in norm and pathology. popup.stage_title Head Shuba Yaroslav M., Доктор біологічних наук Registration Date 09-01-2013 Organization International center of molecular physiology popup.description2 It was investigated the effects of two novel polypeptide inhibitors of TRPV1 from the venom of tropical sea anemone Heteractis crispa, APHC1 and APHC3, on the contractions of (DSM) detrusor smooth muscle from bladders of normal rats. Our results demonstrate that АРНС1 and АРНС3 may be considered as effective inhibitors of bladder of contractili. Modality of action of APHC-polypeptides via themechanisms involving decreased TRPV1-dependent release of tachykinins from bladder afferents and suppression of tachykinins degradation due to their activity as endogenous proteases inhibitors is proposed. Product Description popup.authors Батюк М.Ю. Падурару О.М. Філіпов І.Б. popup.nrat_date 2020-04-02 Close