Search academic texts

Information × Registration Number 0212U008637, 0112U005143 , R & D reports Title Role of pttg gene in the development precancerous abnormalities of liver popup.stage_title Head Sybirna Nataliya Oleksandrivna, Registration Date 09-01-2013 Organization Ivan Franko National University of Lviv popup.description2 In the study of the proliferative activity of hepatocytes of mice, it was found that under conditions of pttg gene knockout proliferative activitypttg of hepatocytes in S-phase of the mitotic cycle decreased by 20.4% compared to those of wild-type mice. It was investigated that the level of cytokine TNF-a in serum was lower in mice pttg-KO by 10.7% compared with those of mice pttg-WT, and TGF-b1 by 17%. Set to reduce set to reduce pttg gene expression in mice developed fibrosis of the liver. The results indicate a significant influence pttg gene in the processes of fibrosis. Product Description popup.authors Афанасьєв Сергій Валерійович Канюка Олена Петрівна Сибірна Наталія Олександрівна Філяк Євген Зіновійович popup.nrat_date 2020-04-02 Close