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Information × Registration Number 0212U008643, 0112U007360 , R & D reports Title Determination of degree of malignant tumors of different histogenesis using domestic monoclonal antibodies popup.stage_title Head Markovych Iryna, Registration Date 28-12-2012 Organization State Centre of Innovation Biotechnologies popup.description2 The purpose of work was the research development of technology of the degree of malignancy of tumors using domestic monoclonal antibodies. Been developed research technology of murine monoclonal antibodies IPO-38, Technical laboratory regulations determining the expression IPO-38 antigen in samples isolated cells and technical laboratory regulations determining antigen expression IPO-38 in tissue samples. Conducted researches of antigen expression level in malignant tumors of different histogenesis, in particular, lymphoid and myeloid forms of leukemia, non-Hodgkin lymphoma and malignant tumors of the central nervous system. Showed a strong heterogeneity investigated cytological and histological variants of malignant tumors by expression of antigen IPO-38. On examples lymphomas of small lymphocytes and tumors of glial origin of varying degrees of malignancy shown that high levels of antigen expression IPO-38 correlates with poor prognosis of the disease. In such a way detection of antigen IPO-38 by help of domestic monoclonal antibodies can be used to assess the degree of malignancy of tumors. Created prototype ELISA test system for the detection of antigen. Product Description popup.authors Афанасьєва К.В. Гриневич Олександр Йосипович Гузик Ольга Йосипівна Думанський Валентин Дмитрович Ліпський Петро Юзефович Литвиненко Володимир Іванович Маркович Ірина Григорівна Оксамитний Віктор Миколайович Поліщук Іван Володимирович Поліщук Ірина Володимирівна Сидоренко Світлана Павлівна Співак Микола Якович Яцук З.О. popup.nrat_date 2020-04-02 Close