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Information × Registration Number 0212U009043, 0112U006008 , R & D reports Title Search and characterization of oncogenes and tumor suppressor genes involved in the initiation and development of gliomas popup.stage_title Head Kavsan Vadym Musiyovich, Registration Date 27-12-2012 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 During a project execution the mitogenic properties and proliferative potential of CHI3L1 and CHI3L2 proteine were investigated. It was found that CHI3L1 stimulates a cell growth and has oncogenic potential. 293_CHI3L1 cell line have obtained which stable produces CHI3L1 protein. CHI3L1 overproduction stimulated the ability of cells for anchorage independent growth, which is one of the most correct indicators of oncogenic cell transformation. To study the oncogenic effect of CHI3L1 in vivo, 293_CHI3L1 cells were implanted into the Wistar rats brain. The intracerebral tumours sized of 1/3 initial whole brain volume have been observed in all rats with implanted 293_CHI3L1 cells. Formation of tumour by the cells that stably express CHI3L1, in the rats brain clearly indicates that this gene is involved in oncogenesis, its overexpression is critical for tumour development, and this phenomenon can be used as a target for anticancer drugs.5481 Product Description popup.authors Єршов Антон Вікторович Арешков Павло Олександрович Балинська Олена Вікторівна Бойко Оксана Іванівна Букреєва Тетяна Василівна Дмитренко Володимир Володимирович Чаусовський Тімур Йосипович popup.nrat_date 2020-04-02 Close