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Information × Registration Number 0212U009058, 0110U002699 , R & D reports Title Development of optical biosensors on the basis of modern nanotechnol popup.stage_title Head Demchenko Alexander Petrovich, Доктор біологічних наук Registration Date 28-12-2012 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 As a result of this study the hybrid nanoparticles were obtained with the functions of molecular recognition and fluorescence response. The technique was developed for modification of nanocrystal - quantum dot- biomembrane surface, which allowed monovalent ligand binding. The introduction of additional amino group the 3-hydroflavone derivative was synthesized for covalent attachment of spacer group. The technique for conjugation of quantum dots and obtaining the intermediate synthetic product with the spacer covalently bound to with 3-hydroxyflavone chromophore. In the studies of conjugate of quantum dots with organic dyes the independence of their spectral response was also obtained. The created fluorescent nanohybrids of organic dye and silver clusters were used for the first time as the ligands that bind to the protein (bovine serum albumin). Product Description popup.authors Демченко Олександр Петрович Канюк Микола Ігоревич Назаренко Володимир Іванович popup.nrat_date 2020-04-02 Close