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Information × Registration Number 0212U009061, 0112U006023 , R & D reports Title Mechanisms of nicotinic acetylcholine receptor signaling in B lymphocytes. popup.stage_title Head Skok Maryna Volodymyrivna, Доктор біологічних наук Registration Date 28-12-2012 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 The results of this work indicate that endogenous acetylcholine is a negative auto- or paracrine regulator of B lymphocyte mitogenic activation. The effect of acetylcholine is mediated by nicotinic acetylcholine receptors of 7 subtype ( 7 nAChRs); their activation inhibits the intracellular signaling cascade including phosphorylation of ERK 1 and 2 kinases. B lymphocyte signaling, accompanied by the increase of intracellular Ca2+, does not require the opening of 7 nAChR ion channel, but is triggered by allosteric (conformational) changes in its molecule stimulated by either agonist or competitive antagonist binding. The rise of intracellular Ca2+ level occurs due to other than 7 nAChR ion channels of the B lymphocyte plasma membrane under the effect of Ca2+ released from intracellular stores. Product Description popup.authors Гергалова Галина Леонідівна Калашник Олена Миколаївна Коваль Людмила Миколаївна Лихмус Олена Юріївна Скок Марина Володимирівна popup.nrat_date 2020-04-02 Close