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Information × Registration Number 0213U000075, 0110U002184 , R & D reports Title To investigate the factors that ifluence brane tumors methastase process in childre for their early diagnostic and treatment popup.stage_title Head Orlov Yury O., Registration Date 16-01-2013 Organization SI "Institute of Neurosurgery named after acad. A.Romodanov, AMS of Ukraine" popup.description2 Report GDR: 129 pages, 21 figure, 27 tables, 175 sources of domestic and foreign literature. Object of study: children with metastatic brain tumors. Objective: to establish the factors that affect the metastasis of brain tumors in children, improve early diagnosis and treatment of metastatic brain tumors in children. Methods: clinical and medical history, radiological, morphological, histological, immunological, genetic and statistical. Embryonic tumors and intracranial ependimomy is the most common form of malignant metastatic brain tumors in children. Together they account for almost 30% of all malignant brain tumors in pediatric populations. Comprehensive studies using clinical, morphological, histological and genetic techniques conducted in children with metastatic brain tumors and is aimed at developing methods of early diagnosis, selection of patients at risk and optimize treatment strategy for improving the quality and duration of life. The introduction of diagnostic and treatment process of modern science and technology (MRI, magnifying optics, mikroinstrumentariy) increased the interest in this problem. Metastatic brain tumors are a heterogeneous group of tumors with different histological structure, character growth, topography. Statistical data show a relative increase in incidence over the past 30 years. Designed indications for surgical intervention, its volume, addition operations other treatments with regard to quality and duration of life of patients. Reduction of postoperative mortality associated with improved preoperative imaging of tumors and their relationships with the surrounding brain tissue, the development of neurosurgical technology, changes in child Neuroanesthesiology and intensive care. The factors that affect the poor prognosis in children with metastatic brain tumors. The structural and biological features of metastatic brain tumors based on location and nature of the tumor growth, especially the immune status of patients, depending on the risk and duration of survival. Object of economic activity are ways of diagnosis, prognosis, and combined treatment of metastatic brain tumors in children. Medical and social indicators characterizing the efficiency of methods of diagnosis, prognosis, and combined treatment of metastatic brain tumors in children: early diagnosis, MRI, CT, neyrosonohrafiya, Doppler, differentiated approach to the selection of the optimal method of treatment, establishing his phasing and sequence. Results and novelty. Established clinical criteria of patients at high risk according to the patient's age (younger children), tumor size, the nature of its growth, the presence of metastases, the nature and volume of transactions, and so on. Studied the morphological, genetic and structural biological features of metastatic brain tumors, which determine the aggressiveness of tumor growth. An analysis of modern diagnostic instrumental methods of examination (nig, CT, MRI). Results of surgical and combined treatment with regard to quality and duration of life of the patient, depending on how radical surgery, histo-biological and topographical features of tumors. Defined indications and contraindications for the various types of combined treatment. Optimized treatment tactics, improved quality and increased life expectancy, reduced mortality and disability of young children with metastatic brain tumors. The practical value of the results. Comprehensive studies using clinical, morphological, histological techniques in children with metastatic brain tumors allowed to determine the factors that affect the appearance of metastases, to develop methods for early diagnosis, identify groups of patients at risk and optimize treatment policy to improve the quality and length of life. Product Description popup.authors Борисова І.О. Васильєва І.Г Довженко С.П.. Канюка В.Ю Лісяний М.І. Малишева Т.А. Олексенко Н.П. Свист А.О. Черненко О.Г. Чопик Н.Г. Шаверський А.В. popup.nrat_date 2020-04-02 Close