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Information × Registration Number 0213U000175, 0110U001156 , R & D reports Title To study bening prostatic hyperplasia and carcinogenesis of prostate after the Chernobyl accident in Ukraine on the basis of clinical? pathologycal and molecular biologycal study popup.stage_title Head Vozianov O.F.; Romanenko A.M., Registration Date 19-02-2013 Organization State Institution "Institute of Urology of AMS of Ukraine" popup.description2 For the first time we have shown that long-term low-dose ionizing radiation exposure leads to overexpression of y-Н2АХ (DNA damage marker) as well as iNOS (oxidative stress marker) and Bcl-2 (apoptosis inhibitor). For these patients firstly revealed chronic atypical proliferative prostatitis (CAPP), that is positive background for prostate cancer. CAPP characterized by pathognomic regions of proliferative inflammatory atrophy (PIA with great DNA damage, high cell proliferation with increased protein expression of y-Н2АХ, iNOS, р53, Bcl-2, Кі-67, and decrease of р16INK4a, p27Kip1, р63 protein expression. In long-term low-dose ionizing radiation conditions PIA for patients with BPH may get value of precancer lesions. Product Description popup.authors Базалицька С.В. Возіанов С.О. Пасечніков С.П. popup.nrat_date 2020-04-02 Close