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Information × Registration Number 0213U000396, 0110U000335 , R & D reports Title Pathogenetic mechanisms of endogenous intoxication formation at traumatic didease popup.stage_title Head Yelsky Viktor Mykolaevich, Registration Date 06-02-2013 Organization Donetsk National Medical University after named Gorky popup.description2 Research object: 300 white rats with a trauma by the Kennons' model, by the crush-syndrome and craniocerebral trauma, 30 control and 20 intact animals. Subject of investigation : lethality, character and number of complications at development of endogenous intoxication syndrome at experimental models of traumatic disease (ТD). Purpose od investigation: determination of mechanisms of endogenous at TD and development of fundamentally new scientific conception and pathogenetic direction of correction for decline of lethality and complications. Research novelty: conception of endogenous intoxication syndrome was formed for the first time at ТD, at molecular level co-operation of violations of the neuroimunnoendocrine regulation and manifestation endogenous intoxication syndrome was studied, the pharmacological approach to correction was explored. Results: at research of every model of ТD two groups were distinguished with a favourable and unfavorable end. It was marked that in groups with the favourable end of ТD there was a tendency to the making progress hypotension, exhaustion of the antioxidant system and immunjdepression. In groups with the unfavorable end of ТD in animal with crush-syndrome in pathogenesis of endotoxicosis a leading place is occupied by the accumulation of toxic substances, violation of their elimination and resorptive mechanism, while at craniocerebral trauma - injury of intracellular homoeostasis and oppressing of immunity. In basis of pathogeny of endotoxicosis at a trauma of Кеnnons - a retentional mechanism comes forward into first place. In connection with the nosotropic role of oxidative stress in genesis of endogenous intoxication at a traumatic damage the effects of introduction of preparations were investigational with an antioxidant and by the antihypoxant orientation of different pharmaceutical groups: Quercetinum, Thioctic acid, Lipin, Thiotriazolin, Mexidolum. Product Description popup.authors Воронін Олег Юрійович Золотухін Сергій Євгенович Зябліцев Сергій Володимирович Кишеня Марія Сергіївна Колєснікова Світлана Віталіївна Коровка Сергій Якович Крюк Юрій Якович Лінчевська Лариса Павлівна Нечепорчук андрій Володимирович Піщуліна Світлана володимирівна Уманський Володимир Якович Чернобривцев Петро Арташесович Якубенко олена Дмитріївна popup.nrat_date 2020-04-02 Close