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Information × Registration Number 0213U000654, 0111U000378 , R & D reports Title To develop new methods ot brachytherapy with the use of HDR in patients with locally advanced cervical cancer. popup.stage_title Head Ivankova Valentina Stepanovna, Доктор медичних наук Registration Date 01-03-2013 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 Research Report: 79 pages, 24 figures, 3 tables, 4 applications, 220 sources. Object of study - 70 patients with locally advanced cervical cancer (LACC). Purpose - to increase the efficiency of coupled radiation therapy (XRT) of patients with locally advanced cervical cancer by developing new techniques brachytherapy with high activity sources during the XRT. Research methods and equipment: clinical, laboratory, radiodiagnostic, dosimetry. Simulator irradiation session - "SimView" 3000 (Siemens, Germany), TERATRON, AGAT-VU (MDR), GUNE SOURCE (HDR), US-mashines "Aloca" - FLEXUS, apparatus for magnetic resonance imaging (MRI) "Magnetom - Vision - Plus - System "(Siemens), universal dosimeter PTW Freiburg" Unidose E ". The study included 70 patients with LACC that received XRT and divided into two main and control groups. In the main group I included 22 patients with LACC who contact brachytherapy was performed on the unit Gyne Source high-dose radiation (HDR) mode single focal dose (SFD) 5 Gy t A 2 times a week for a total focal dose (TFD) 30 - 35 Gy in 6 - 7 fractions; II core group of 20 patients LACC what contact brachytherapy performed on the unit Gyne Source mode SFD 7 Gy And so on 1 day a week, SFD = 28 - 35 Gy for 4 - 5 fractions. A control group of 28 patients lay LACC what contact brachytherapy performed on apparatus AGAT-VU with an average dose rate (MDR) in the SFD in point A - 8 Gy x 1 time for 6 - 7 days, TFD = 40 - 48 Gy in 5 - 6 fractions. Indications and contraindications for elaboration mode HDR for patients with cervical cancer. Received immediate treatment results and clinical dosimetric evaluation patients with LACC evidence of cervical cancer show the effectiveness of elaboration modes brachytherapy and unavailability intolerable toxicity applied methods provided quality of before XRT training. Pointed to increased tumor regression in patients 2 group relatively resistant forms of LACC using from HDR BT in point A 7 Gy x 1 day a week, TFD - 35 Gy, which do not affect the toxicity of the treatment. The analysis of early local toxicity SLT patients with LACC on machines Gyne Source with high activity Co60 source. Identified a means of preventing local toxicity occurred during treatment were developed the techniques, thus avoiding excessively early radiation reactions (above level II) to critical organs. CERVICAL CANCER, COMBINED RADIOTHERAPY, EXTERNAL BEAM RADIOTHERAPY, BRACHYTHERAPY, EARLY RADIATION REACTION. Product Description popup.authors Іванкова Валентина Степанівна Бакай Ольга Олексіївна Барановська Лідія Михайловна Галяс Оксана Миколаївна Скоморохова Тетяна Володимирівна Хруленко Тетяна Валерівна Шевченко Галина Миколаївна popup.nrat_date 2020-04-02 Close