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Information × Registration Number 0213U000728, 0110U003408 , R & D reports Title To develop system of methods of differential diagnosis and optimization of treatment of patients with degenerative diseases of retina and choroid popup.stage_title Head Pasyechnikova Natalya V., Registration Date 13-03-2013 Organization The Filatov Research Institute of Diseases and Tissue Therapy popup.description2 Object of study: cytokines in the blood of patients with diabetic retinopathy, the thickness of the rim of the optic nerve disc and retinal nerve fiber layer, fluorescence of vitreous, methylene blue, circulation of the choroid, vitreous hemorrhage in diabetic retinopathy. Purpose: to develop a system of differential diagnosis methods and optimize the treatment of patients with degenerative diseases of the fundus through the study of morphological characteristics of retinal nerve fiber layer and optic nerve disc, the state of blood-retinal barrier and expression patterns of pro- and anti-inflammatory cytokines in patients with diabetic retinopathy, to study the feasibility of a solution of methylene blue for angiography of the retina, to study the characteristics of blood circulation in the choroid in patients with subretinal neovascular membrane in wet age-related macular degeneration, to study the characteristics of frequency-dependent attenuation of broadband pulse echo signal in the vitreous during transient vitreous hemorrhage. Results: 1. It was proved a significant positive correlation between baseline study of cytokines in the blood of patients with diabetic retinopathy and progression of the disease. 2. For the first time it was shown that the type of diabetes does not changes of morphometric parameters of the optic nerve disc in patients with diabetes. 3. For the first time it was studied state of blood-retinal barrier depending on the stage and severity of the pathological process in diabetic retinopathy according to vitreous fluorometry. 4. Possibility of retinal angiography in rabbits with 1% and 2% solution of methylene blue was first proved. 5. It was found that blood flow in eyes in patients with wet age-related macular degeneration according to the data of rheoophthalmography disturbed in all patients. 6. With ultrasonic spectrum analyzer in transmission mode for the first time studied the acoustic performance of the contents of the vitreous cavity in transient vitreous hemorrhage after closed vitrectomy in patients with diabetic retinopathy. Product Description popup.authors І.Н. Асауляк А.О. Невська В.С. Репях Задорожний Олег Сергійович Зборовська Олександра Володимирівна Кацан Сергій Володимирович Ковальчук Олександр Георгійович Король Андрій Ростиславович Кустрин Тарас Богданович Н.М. Крижова Н.М. Кушнір Насінник Ілля Олегович Науменко Володимир Олександрович Пасєчнікова Наталія Володимирівна Путієнко Олексій Олексійович popup.nrat_date 2020-04-02 Close