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Information × Registration Number 0213U001021, 0110U000181 , R & D reports Title Analysis of neurobiological mechanisms in forming of long-term neuropsychiatric effects after the evolutionary brain's irradiation popup.stage_title Head Loganovsky Kostyantyn, Bazyka Dimitry, Registration Date 09-01-2013 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Object of study: It is inspected 340: 120 - irradiated in utero, 80 - at the age of 0-1 years and 140 unexposed persons born in 1985-1986. Objective: To determine the neurobiological mechanisms of a young age neuropsychiatric effects of prenatal exposure period and the age of 0-1 years as a result of the Chernobyl disaster. Methods - сlinical, neuropsychological, neurophysiological, іmunological, statistical. A local database of persons exposed in utero and at the age of 0-1 years following the Chernobyl disaster was found. Increase in the frequency of nervous system and mental diseases (through somatoform, anxiety and depressive disorders) was found. Trend towards lower verbal IQ and general IQ was found with normal level of non-verbal IQ. Neurophysiological features was found - reducing the delta, theta, alpha-i power more in the fronto-temporal regions of the left hemisphere, which may indicate a decrease in activity of the hippocampus. Trend aimed at blocking the entry of lymphocytes in apoptosis was found. Changes in the immune system that can lead to autoimmune processes and disturbance antitumaral and antiviral immune responses. Obtained the first data on the biological mechanisms of radiation-induced lesions of the developing brain. Certain pathogenesis neurocognitive deficits and neurophysiological disorders may consist in radiation-induced disruption of the regulation of apoptosis. 13 scientific publications are published, 9 reports at conferences and seminars. Product Description popup.authors Ільєнко Ірина Миколаївна Андоній Галина Вікторівна. Антипчук Катерина Юріївна Бєляєв Олег Анатолійович Бєляєва Надія Володимирівна Бабенко Тетяна Федорівна. Бомко Марія Олександрівна Гасанов Анвер Аждарович Голярник Наталія Анатоліївна Гресько Марина Володимирівна Зданевич Наталія Анатоліївна Колосинська Олена Олександрівна. Куц Костянтин Володимирович Логановська Тетяна Костянтинівна Лясківська Олена Володимирівна Мазніченко Оксана Леонідівна Чукмасов Дмитро Сергійович Чумак Станіслав Анатолійович Чупровська Наталія Юріївна Ярошенко Жанна Степанівна popup.nrat_date 2020-04-02 Close