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Information × Registration Number 0213U001071, 0112U002409 , R & D reports Title Oxidative mechanism contribution to interaction of radiation and stress impact upon higher nervous activity of rats popup.stage_title Head Talko Victoria Vasilivna, Доктор медичних наук Registration Date 11-01-2013 Organization Research Centre for Radiation Medicine popup.description2 Object: higher nervous activity of white rats after exposure to non-radiation stress-agent. Goal: to estimate the significance of oxidative component in shaping of higher nervous system response to exposure to measured stress using substances with antioxidant properties. Methods: behavioral (shuttle and Scinner boxes), foot-shock, statistical. Based on behavioral indices taken at different time intervals after exposure to stress with and without antioxidant means (alfa-tocopherol and ascorbic acid) as well as regression analysis results, the conclusion was made that oxidant component has a significant, though not leading, role, significance of which depends on the stage of its development. Directly after exposure to stress it limits the reaction realization, and later, corresponds to development of inhibition and discrepancy between excitation level and efficiency of higher nervous activity. Since the significance of free radical processes differs at different stages of stress-response, different pattern of interaction of radiation and nonradiation agents could be expected. Product Description popup.authors Варецький В'ячеслав Васильович Дмитрієва Інна Рудольфівна Пахольченко Вікторія Мирославівна Ракочі Олександр Григорович Тукаленко Євген Валерійович Шелковський Микита Володимирович popup.nrat_date 2020-04-02 Close