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Information × Registration Number 0213U001178, 0111U000609 , R & D reports Title 3 Determine the principal molecular mechanisms of drug resistance in patients with chronic myeloid leukemia popup.stage_title Head Tretyak N.M., Доктор медичних наук Registration Date 22-01-2013 Organization Kiev Research Institute of Haematolojy and Blood Transfusion popup.description2 Object of research - 32 patients with chronic myeloid leukemia (CML), peripheral blood cells and bone marrow cells of patients with CML. We have used clinical, hematological, cytogenetic, molecular-genetic, immunological methods.It is established, that 87,5 % of patients with high risk on index Socal had an inefficiency of therapy of tyrosine kinase inhybitors (TKI). In patients with resistance to TKI is increase of cells-progenitors, with expression protein Pgp-170, quantity and in a bone marrow - tumoral cells with raised expression Bcl-2 revealed. In patients with CML is increase proliferative activity in vitro cells-progenitors detected. In patients with CML In patients with CML prior to the beginning of treatment high frequency of cases of evolution clonal anomalies of chromosomes is revealed. Medicine. Product Description popup.authors Білько Надія Михайлівна Гордієнко Алла Іванівна Загоруйко Наталія Леонідівна Перехрестенко Тетяна Петрівна Шороп Євген Валерійович popup.nrat_date 2020-04-02 Close