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Information × Registration Number 0213U002048, 0112U004106 , R & D reports Title Synthesis of optically active aminophosphonates cyclic and noncyclic structure popup.stage_title Head Kukhar V.P., Registration Date 10-01-2013 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 Asymmetric synthesis of 2-amino-3,3,3-trifluoropropylphosphonate esters using addition of anions derived from dialkyl methylphosphonates to (SS)-N-tert-butanesulfinyl (3,3,3)-trifluoroacetaldimine as chiral auxiliary have been developed. The excellent diastereoselectivity, good yield and short reaction time are the noteworthy advantages of the described method. Synthesis of phosphonodipeptides from enantiomerically pure 2-amino-3,3,3-trifluoropropylphosphonate ester using a coupling reaction at the deactivated N-terminal position was successfully performed. Enantiomerically pure (2S,3S)- and (2R,3S)- -trifluoromethyl isoserine derivatives were obtained in good yield and high diastereoselecitvity by Mannich addition of enolates to (SS)-N-tert-butanesulfinyl (3,3,3)-trifluoroacetaldimine. Product Description popup.authors В.Д. Романенко М. В. Шевчук О. Є. Сорочинський popup.nrat_date 2020-04-02 Close