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Information × Registration Number 0213U002053, 0110U000976 , R & D reports Title Early development stages of human malignant, autoimmune and neurodegenerative disorders popup.stage_title Head Ryndych Alla Volodymyrivna, Доктор біологічних наук Registration Date 14-01-2013 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 The project aim is the identification and characterization of potential molecular markers of human cancer, autoimmune and neurodegenerative diseases. It was determined that histone deacylase inhibitor (S78454) affected the epigenetic histone modification, alters 11q13 locus, which undergoes translocations in lymphoma from the cells of mantle zone. Endocytosis adapter protein intersectin 1 is shown to be colocalized in the dendrites of rat hippocampal neurons with STOP protein, which regulates the Ca-calmodulin-dependent stability of microtubules in neurons and is required for some forms of synaptic plasticity. It was shown that 293_CHI3L1 cells, which are stably produce CHI3L1 protein, have the ability for anchorage-independent growth and to form foci in soft agar. These results suggest about oncogenic properties of the CHI3L1 protein. Based on the expression of 20 genes a clasterization of 225 glioblastoma samples and 71 samples of normal brain by self-organized Kohonen maps. Checking signatures of gene expression in the test sample of 5 glioblastoma samples and 10 samples of normal brain showed its suitability for differentiating of glioblastoma and normal brain samples. A tendency to increased expression of leucyl tRNA synthetase (LARS1) gene have revealed in a cells culture of lung cancer. It was found that elevated failure rate of translation caused by the presence of РТІ-1 protein in certain cells may be served as one of factors of its oncogenic transformation. Product Description popup.authors Єршов А.В. Бояршин К.С. Висловух А.А. Гудзера О.Й. Дергай М.В. Дмитренко В.В. Кавсан В.М. Коваленко О.П. Крикливий І.А. Крикливий І.А. Негруцький Б.С. Новосильна О.В. Новохацька О.В. Порубльова Л.В. Скрипкіна І.Я. Тукало М.А. Циба Л.О. Шалак В.Ф. Яремчук Г.Д. popup.nrat_date 2020-04-02 Close