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Information × Registration Number 0213U002135, 0112U001997 , R & D reports Title Viral protein induced malignant cell transformation: unknown mechanisms popup.stage_title Head Kashuba Elena Vitaliivna, Доктор біологічних наук Registration Date 15-01-2013 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 This project is devoted to the study of the molecular mechanisms of malignant transformation of cells by infection with viruses that do not integrate into the human genome, for example, DNA virus Epstein-Barr virus (EBV) and hepatitis C virus RNA Rights (HCV). In both cases, malignant transformation is due to the action of viral proteins that exhibit a number of similarities. Certain proteins as EBV and HCV alter the cell cycle and prevent apoptosis of infected cells. During the reporting period coding genes EBNA-3 and EBNA-6 was proklonovano in eukaryotic expression vectors (GFP). Found that EBNA-6 binds to mitochondrial ribosomal protein MRRS18-2 (S18-2) and translates it into the nucleus. Product Description popup.authors Буднікова Дар'я Володимирівна Бучинська Любов Георгіївна Кашуба Олена Віталіївна Ковалевська Лариса Миколаївна Романець Ольга Леонідівна Шабельник Мар'яна Юріївна Юрченко Марія Юріївна popup.nrat_date 2020-04-02 Close