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Information × Registration Number 0213U002167, 0110U005770 , R & D reports Title Development of biotherapy drugs (biomolecules) by RNA-based technologies to correct molecular disorders found in tumor cells popup.stage_title Head Chekhun Vasyl Fedorovych, Registration Date 16-01-2013 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 The present study was undertaken to investigate the status and role of iron metabolism in drug-resistant breast cancer cells. We demonstrate that human MCF-7 breast cancer cells with an acquired resistance to chemotherapeutic agents, doxorubicin and cisplatin, exhibit extensive alterations in the cellular iron homeostasis characterized by marked alterations in the level of intracellular "free iron" and proteins responsible for the cellular uptake, storage, and export of iron. Furthermore, the results of the present study demonstrate that targeted down-regulation of over-expressed ferritin light chain protein by miR-133a microRNA increases sensitivity of MCF-7/DOX and MCF-7/CDDP cells to doxorubicin and cisplatin. This suggests that correction of intracellular iron metabolism may also be a potential approach to overcome resistance of breast cancer cells to chemotherapeutic agents. Product Description popup.authors Борікун Т.В. Кунська Любов Миколаївна Лісовський Ігор Леонідович Лук'янова Наталія Юріївна Налєскіна Леся Анатоліівна Чехун Василь Федорович popup.nrat_date 2020-04-02 Close