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Information × Registration Number 0213U002332, 0110U000978 , R & D reports Title Design of condensed heterocyclic compounds, regulators of nucleic acids biosynthesis enzymes popup.stage_title Head Dubey Igor, Registration Date 23-01-2013 Organization Institute of molecular biology & genetics popup.description2 Methods of the preparation of condensed heterocyclic compounds of various classes were developed. Their biological activity was studied in the systems of transcription based on RNA polymerase T7, DNA relaxation by topoisomerase I and telomeric DNA synthesis by telomerase in vitro. Inhibitors of these enzymes active at micromolar concentrations were found. Mechanisms of their inhibition activity were investigated by biochemical and physico-chemical methods and using the computer modeling. Testing on cell models revealed the compounds with antiviral action against herpes, Epstein-Barr and hepatitis C viruses, antibacterial activity against M. tuberculosis, and antifungal activity, whose efficiency is close or superior to that of corresponding medical agents (ribavirin, rifampycin, fluconazole etc). Compounds with antitumor activity at micro- and nanomolar concemtrations were found. Product Description popup.authors Ільченко Микола Миколайович Алексєєва Інна Володимирівна Дубей Лариса Василівна Костіна Валентина Григорівна Костенко Олександр Миколайович Криворотенко Дмитро Валентинович Кузів Ярослав Богданович Лисенко Надія Антонівна Негруцька Валентина Володимирівна popup.nrat_date 2020-04-02 Close