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Information × Registration Number 0213U002447, 0110U001289 , R & D reports Title Investigation of antioxidant and anticancer properties of nanoliposomes and nanoparticles on the base of cluster rhenium compounds popup.stage_title Head Shternenko Nataly Ivanovna, Registration Date 29-01-2013 Organization Dniepropetrovsk national university popup.description2 Research object - biochemical mechanisms in basis of antioxidant and anticarcinogenic properties of cluster compounds of rhenium in nanoliposom forms and nanoparticles. A purpose is development of bases of biochemistry: study of molecular mechanisms of pathological processes and ways of their correction, by the study of oxidative stress of living organisms and methods of braking of free-radical processes, development of new drugs and therapeutic methods based on organometallic compounds, research of biochemical characteristics of liver cells of treated animals. Research methods are biochemical, photocolorimetric and spectrofotometric, cytochemical and fluorescence analysis, the methods of the circular dichroism and mathematical statistics. The effect of trans-and a number of cis-dicarboxylates of di-rhenium on tumor development, morphological and biochemical descriptions of erythrocytes and parameters of oxidative stress of blood, in the model of rats cancerogenesis, at separate administration of them and together with cisplatin are investigated. The dependence is first well-proved between the structure of cis-dicarboxylates of di-rhenium (III) and by their capacity for activating of erythrocyte superoxide dismutase and hepatoprotective function of rhenium compounds. Industries of application are biochemistry, biophysics, physiology, pharmacology. The users of results - scientific establishments, higher educational ones which carry out research and (or) educational process in indicated and contiguous industries are possible. Product Description popup.authors Антропов С.М. Бабій С.О. Дьомшина О.О. Леус І.В. Семенов С.С. popup.nrat_date 2020-04-02 Close