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Information × Registration Number 0213U002687, 0110U002250 , R & D reports Title Development of main criterion for application of silica sorbents with biomimmetic dye-ligands for recieving diagnostic and terapeutic protein preparation popup.stage_title Head Danysh Taras Vasylovych, Registration Date 04-02-2013 Organization LVIV RESEARCH INSTITUTE OF BLOOD PATHOLOGY AND TRANSFUSIONAL MEDICINE popup.description2 Objective: To create a set of bio-targeting sorbents based on makroporous silica matrix and dye-ligand conditions justify their application of fast analysis and purification of proteins from biological material. Methods: chemical synthesis, fractionation, affinity and gel permeable chromatography, centrifugation, electrophoresis, and others. As a result of work obtained following scientific and practical results: a comparative study of the properties of silica sorbents and sorbents based on Toyopearl, the conditions obtained by applying sorbents for the analysis and separation of clotting factors, investigated the esterase activity of coagulation factors in plasma subfractions with using a specific chromogenic substrates, the comparative analysis of protein fractions biological fluids obtained after dye-ligand chromatography. Novel sets sorbents suitable for research proteomics of biological fluids. Degree of implementation: application of laboratory regulations biomimetic sorbents in proteomics analysis, acts of implementations, reports on international scientific conferences, publications in the scientific literature, patents, new technology. Application: blood transfusion stations, chemical and pharmaceutical companies, scientific research organizations. Effectiveness: combining biospecific chromatography with other methods facilitate research of proteomics. Bioimimetic sorbents can be used in selection technology of blood protein factors, including recombinant. Published 47 scientific papers, including one patent and one patent application for the invention. Product Description popup.authors Вороняк М.І. Вус М.М. Даниш Т.В. Дульцева Н.А. Дяків Х.І. Мадич С.Є. Орлова Л.В. Шурко Н.О. popup.nrat_date 2020-04-02 Close