Search academic texts

Information × Registration Number 0213U003177, 0111U000132 , R & D reports Title Study the peculiarities of traumatic brain disease development popup.stage_title Head Shevaga Volodymyr Mykolayovych, Registration Date 29-01-2013 Organization Danylo Halytsky Lviv National Medical University popup.description2 Objective: To study the peculiarities of traumatic brain disease development for the prevention of long-term effects of traumatic brain injury, improvement of treatment of patients remote consequences of cranio-cerebral trauma, improving the quality of life and rehabilitation of these patients. Methods: complex clinical neurological examination, a Minnesota Multiphasic Personality Inventory (MMPI), Mini Mental State Examination (MMSE), Frontal lobe Assessment Battery (FAB), clock drawing test. In patients with acute brain injury of mild to moderate severity syndrome revealed mild to moderate cognitive impairment. FAB among the three tested neuropsychological test was the most sensitive for the diagnosis of post-traumatic cognitive dysfunction. In response to mechanical damage of the an adaptive state of CNS develops. It is a set of structural and functional changes in the nervous system, which have complex morphological basis and involve traumatic necrosis and degeneration. Traumatic brain disease develops as individual response in the form of vascular liquor dynamic, biochemical and metabolic changes leading to the development of apoptosis, the severity of which determines the individual dynamics of the process. It was also established that development of oxidative stress, nitrosative stress, endogenous intoxication, chronic inflammation with an autoimmune component are among important pathophysiological processes of traumatic brain disease development. MMPI revealed specific psycho-emotional changes that have characterized the development of depressive-hypochondriac syndrome in patients with post-traumatic encephalopathy. Based on the identified neuropsychological features of acute and long-term periods of TBI an automated method for testing human cognitive functions was developed. The complex of low molecular weight polypeptide fractions (cortexin) reduces the cognitive deficits in rats with acute head injury and has a pronounced neuroprotective and antioxidant effects. A clinical study of the effect of the medicinal preparation (cortexin) in patients in the acute and long-term periods of TBI established ability of the drug to restore significantly cognitive function and positive pathogenetic influence. Product Description popup.authors Задорожна Божена Володимирівна Кухленко Ольга Ярославівна Кухленко Ростислав Володимирович Паєнок Анжеліка Володимирівна popup.nrat_date 2020-04-02 Close