Search academic texts

Information × Registration Number 0213U004063, 0110U001009 , R & D reports Title Determine the dynamics of changes of daily and seasonal rhythms functioning of the hypothalamus-pituitary- adrenоcortical and sympatho-adrenal system during the hypopinealism popup.stage_title Head Bondarenko Ludmila Olexandrivna, Registration Date 31-01-2013 Organization Ukrainian Research Institute of Endocrine Diseases Pharmacotherapy popup.description2 The object of study - the hypothalamus, pituitary, adrenal glands, blood. Purpose - to determine chronorhythmus functioning adrenal glands and regulate their centers at long hipopinealizmi. Methods - fluorometric, ELISA, histological, morphometric and statistical.On sexually matured male rabbits in the dynamics studied the influence of the hipopinealism induced by long round-the-clock lighting, on hypothalamic-pituitary-adrenal and sympathoadrenal systems, as well as the possibility of the normalization of the structure and functions of these bodies by a course of treatment with melatonin against the restoration of natural light conditions. Found that in rabbits (unlike rats) are characterized by diurnal changes of catecholamines and glucocorticoids in the same way as it does in humans. Proved that light at night should be considered as a stress factor. It is shown that a deficit of melatonin at hipopinealism there desynchronosis noise adrenals by destructive changes in suprahiasmatic and paraventricular nucleus of the hypothalamus, the pituitary adrenocorticotropic and melanotropic cells and in medulla and cortex of the adrenal gland. Obtained pathogenetic model of a hipocorticism of neuroendocrine origin. Restoration of the natural light regime is unable to normalize the structure and function of the studied organs. A course of treatment with melatonin has a positive effect on the hormonal activity and the morphology and function of hypothalamic-pituitary-adrenal system aimed at normalization the manifestations of desynchronous aminergic glucocorticoid and adrenal function is not able to fully restore the damaged characteristic for a hipocorticism of neuroendocrine origin. Areas of use - endocrinology, physiology, pathophysiology. Product Description popup.authors Бастригіна Ала Олександрівна Беретар Амір Рустамович Бондаренко Людмила Олександрівна Бурма Тетяна Юхимівна Волохов Ігор Вікторович Гєворкян Аіда Рубенівна Горбач Тетяна Вікторівна Губіна-Вакулік Галина Іванівна Завадська Наталія Володимирівна Козак Вікторія Анатоліївна Оксюта Юлія Іванівна Сергієнко Лоріана Юріївна Сидорова Ірина Василівна Сотник Наталія Миколаївна Черевко Ганна Миколаївна popup.nrat_date 2020-04-02 Close