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Information × Registration Number 0213U004437, 0112U001715 , R & D reports Title Development of cheap SEIRA and SERS enhanced nanostructured substrates for applied biochemical tasks popup.stage_title Head Kharkyanen Valeriy, Registration Date 16-12-2013 Organization Institute of physics NASU popup.description2 During the project an enhancement of optical signals from model molecule on gold nanocrystals was theoretically calculated and simulated. The enhancement factors were determined. The optimal technological parameters for producing an effective nanostructured surfaces for SEIRA technique were investigated. Two types of gold nanoprism with the sizes ? 100 nm and ? 5 ?m (the thickness was not exceeding 40 nm) were characterized by optical methods. The nanoprisms were synthesized at Institute of Colloid Chemistry. The work concerning the modification of gold substrates for SERS spectroscopy using optical interference scheme for cultivation and concentration nanoprisms in areas of maximum light intensity was done. It was proved and demonstrated that the use of gold as a rough substrate for cell imaging is more effective than existing cover glass for microscopy. The results of Raman spectroscopy, microscopy and biochemical methods showed that the gold particles were adsorbed better on the tumor cell surfaces than normal ones. A study of structural changes in the tumor cells under the influence of Au nanocrystals was done. The lab samples of gold surfaces for SEIRA and SERS spectroscopy were created. It was shown that gold nanocrystals can be used as markers for the diagnosis of cells from tumor tissue. Product Description popup.authors Бойко Віталій Володимирович Довбешко Галина Іванівна Риндер Анна Д.митрівна Фенюк Ольга Володимирівна popup.nrat_date 2020-04-02 Close