Search academic texts

Information × Registration Number 0213U004642, 0111U000613 , R & D reports Title To define risk factors of beginning infectiously-inflammatory complications in patients with acute and chronic leukemia by mielogical origin popup.stage_title Head Fedorovskaya Ye.A., Registration Date 20-12-2013 Organization Kiev Research Institute of Haematolojy and Blood Transfusion popup.description2 Research object: patients with acute and chronic myeloid leukemia (108 persons), microorganisms (507 cultures). Research methods: clinical-laboratory, haematological, immunocytochemical, microbiological, immunological. In patients with AML and CML the factors of risk of the IIC origin identified: clinical - cytopenia of different origins (leucopenia <1,06 Г/л, erythropenia <2,36 Т/л, thrombocytopenia <19,37 Г/л), increase of intoxication and temperature reaction up the of febrile values; microbiological - are signs of dysbiosis, which are registered in biotopes of URT in 82,8 % persons (at AML) and in 77,3 % (at CML): the presence of conditionally of pathogenic bacteria in diagnostically significant titers >100000 CFU/ml, the decrease of number oral streptococci and the substitution them on enterococci, the colonization by yeast and filamentous fungi; immunological - increase of the index СD4-lymphocyte, reduction of completeness of phagocytosis. Violation of microecology of bowel - absence of bifidobacteria, decrease of number of lactobacilli, increase of quantity of enterococci - corrected using probiotical preparation. The inclusion of the Spirulina Platensis to complex treatment of patients helped improve the parameters of cellular immunity. It was proposed mathematical model for predicting the risk of IIC and has developed a program of comprehensive diagnosis and prevention. Social-medicine effect. Medicine. Product Description popup.authors Басова О.В. Мельник О.А. Немировська Л.М. Рибальська А.П. Скачкова Н.К. Третяк Н.М. popup.nrat_date 2020-04-02 Close