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Information × Registration Number 0213U004776, 0113U002762 , R & D reports Title Biosafety and issues of mutual adaptation of natural and artificial nanostructures in biomedicine and genetics: natural science and bioethical aspects popup.stage_title Head Kundiev Yurii Illich, Registration Date 25-12-2013 Organization National Scientific Centre for Medical and Biotechnical Research popup.description2 As a result of this work it was shown that artificial skeleton nanoparticles with well defined structure and high reactivity and penetration is the most suitable material for constructing of hybrid nanosystems with natural biomolecules. The methods used for their combination with proteins are complex, long-lasting and costly. However, the use of modern computer technology, including computer simulation (in silico) of natural interaction of proteins with nanoparticles can greatly facilitate purposeful search of the ways for development of innovative nanosystems and assessment of their potential impact on the human body. The authors demonstrate the results on computer simulation of the interaction of cytochrome P450 isoform (CYP2E1), which metabolize nearly 10 % types of xenobiotics that enter the body, with a single-layer carbon nanotubes of different diameters and graphene plate. Product Description popup.authors Скребцова Катерина Вікторівна Смалько Петро Якович Чащин Микола Олексійович popup.nrat_date 2020-04-02 Close