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Information × Registration Number 0213U004854, 0113U003595 , R & D reports Title Development of a new synthetic approach to nitrogen-containing heterocycles based on tandem reactions of tetrahydropyridines, indolizines and azepines with alkynes in the presence of OH- and NH-acids popup.stage_title Head Tolkunov Sergey Volodimir, Registration Date 26-12-2013 Organization The L.M.Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry popup.description2 Research object - tetrahydrobenzothienopyrido[2,1 -a]isoindoles, tetrahydrobenzofuropyrido[2,1 -a]isoindoles, isoquinolines, containing a tertiary (bridgehead) a nitrogen atom. An aim of work is development of methods of synthesis of indolizines, tetrahydrobenzothienopyrido[2,1 -a]isoindoles, tetrahydrobenzofuropyrido[2,1 -a]isoindoles, using a domino reaction and isoquinolines containing tertiary (bridgehead) a nitrogen atom. Production and transmission of samples thieno[3,2-c] pyridines Russian side for the joint study of transformations under the action of activated alkynes. Research methods are methods of organic synthesis, mass- and NMR- spectroscopy, X-ray diffraction analysis. The methods of receipt of tetrahydrobenzothienopyrido[2,1 -a]isoindoles, tetragidrobenzofuropyrido [2,1-a]isoindole, and isoquinoline containing a tertiary (bridgehead) a nitrogen atom, are worked out by cyclization of corresponding 2 - (2-benzo[b]furan-3-ethyl ) -1,3-izoindolinildiones and 2 - [2 - (aryl) ethyl]-1H-isoindole-1, 3 (2H)-diones in polyphosphoric acid. Unusual cyclization reaction of 2 - (2-benzo [b] furan-3-ethyl) -1,3-izoindolindiones and 2 - [2 - (aryl) ethyl]-1H-isoindole-1, 3 (2H)-diones in polyphosphoric acid, are accompanied by auto-reduction of indolizine cycle. A general way of constructon of 1-(2-carboxyphenyl)-benzothieno[2,3-c]pyridines by domino reactions, which proceed in the cyclization of 2- (3-oxo-4-phenylmercaptobutyl)-1,3-izoindolindiones in polyphosphoric acid are proposed. This results can also be used in preparative chemistry of heterocyclic compounds for the synthesis of biologically active substances to create new drugs Product Description popup.authors Єреско Олександр Борисович Толкунов Валерій Сергійович Толкунов Сергій Володимирович popup.nrat_date 2020-04-02 Close