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Information × Registration Number 0213U004872, 0110U004646 , R & D reports Title Functional bionanomaterials for medical diagnostics of oncological diseases popup.stage_title Head Kashuba Vladimir Ivanovich, Registration Date 26-12-2013 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 It has been proven the possibility of detection in plasma and tumor tissue secretory proteins determine which can be used to develop protocols cancer diagnostics based on surface plasmon resonance. It was analyzed using a computer program Swiss-Model Version 3.5 charge state of Staphylococcus aureus protein A and has been shown preservination of its linear conformation, that is optimal for the subsequent oriented immobilization of immunoglobulins. It was compared the immobilization of Staphylococcus aureus protein A on different types of surface of gold films. It was found that the optimal way was surface modification by thiocyanate. It was investigated interaction between complementary immunoglobulins on three types of surfaces by the method of surface plasmon resonance. It has been shown that only a consistent surface treatment by KNCS and protein A created the conditions necessary for oriented immobilization of immunoglobulins on the gold surface. Product Description popup.authors Болтовець П.М. Геращенко Г.В. Гордіюк Василь Васильович Кашуба О.В. Кравченко С.О. Снопок Б.А. popup.nrat_date 2020-04-02 Close