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Information × Registration Number 0213U004873, 0110U006122 , R & D reports Title Designing and efficiency reserch of the recombinant baculovirus vectors for gene and vaccinotherapies popup.stage_title Head Strokovskaya Lyudmila Ivanovna, Registration Date 26-12-2013 Organization Institute of Molecular Biology and Genetics popup.description2 Transduction of fetal mouse fibroblast by baculovirus vector with beta-interferon gene were used for obtaining vector cells for in vivo experiments. Injection of these cells leads to inhibition of tumor growth and elevation of life expectancy of experimental animals. These data coincide with our in vitro research results. Coculturing of Lewis lung adenocarcinoma cells with fetal mouse fibroblasts which expressed beta-interferon had shown inhibition of tumor cells proliferation. Treatment of recombinant baculoviruses by polyethylenimin (PEI 25K) protected virus against complement-mediated inactivation in vitro. Use of recombinant baculovirus with regulatory sequences oriP/EBNA1 permitted to extend the duration of expression transgene to 60 days. Product Description popup.authors Анопрієнко О.В. Вагіна І.М. Гончарова Л.О. Зінченко В.А. Захарук О.А. Кіхно І.М. Чащина Л.І. popup.nrat_date 2020-04-02 Close