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Information × Registration Number 0213U004877, 0110U004756 , R & D reports Title The role of ion exchange membrane processes in the regulation of cyclosporine- sensitive pore and free radical reactions in mitochondria popup.stage_title Head Sagach Vadym Fedorovych, Registration Date 26-12-2013 Organization Institute of Physiology named after O. Bogomoletz NAS of Ukraine popup.description2 The effect of potential-dependent Na+- and K+-uptake on the membrane potential (??m), oxygen consumption and reactive oxygen species (ROS) production in mitochondria was studied. The dependence of ROS production on ??m, and its decrease due to Na+- and K+-induced membrane depolarization was established. The critical dependence of ROS production on calcium was established. It was shown that NO-synthase activity contributes ~20% in Ca2+-dependent ROS production, which was as well sensitive to ??m and decreased with Na+- і K+-induced depolarization. Product Description popup.authors Акопова Ольга Валеріївна Бурий Віталій Олексієвич Колчинська Людмила Іллівна Маньковська Ірина Микитівна Носарь Валентина Іванівна Сагач Вадим Федорович popup.nrat_date 2020-04-02 Close