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Information × Registration Number 0213U004895, 0110U005689 , R & D reports Title Biological activity and safety of nanomaterials that could be used in development of vector systems of antitumor drugs popup.stage_title Head Chekhun Vasyl Fedorovych, Registration Date 27-12-2013 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 We studied cytototoxic effects of nanomaterials of different origin (ferromagnetic and colloid gold) on lipid and energy metabolism in vitro. We found that impact of magnetic fluid and colloid gold nanoparticles on Ehrlich ascetic carcinoma cells caused reactive oxygen species (ROS) generation and activation of free radical processes. These changes resulted in cell death due to apoptosis. Activation of free radical processes caused by metal-containing materials also reduced functional activity of mitochondria and elevated membrane fluidity. Based on the acquired data, we proposed a new method of quantitative analysis of ROS generation changes in cells, which could be used for determination of biological activity and safety of nanomaterials of different origin. Data acquired during the fundamental development should be taken into account in further studies aimed at development of nanosystems based on metal-containing nanomaterials for vector delivery of antitumor drugs to the biological target . Product Description popup.authors Бурлака Анатолій Павлович Ганусевич Ірина Іванівна Демавш Дмитро Валерійович Лозовська Юлія Валеріївна Лук'янова Наталія Юріївна Мельник Наталія Миколаївна Налєскіна Леся Анатоліївна Стеблянко Тамара Ісаківна Тодор Ігор Миколайович Трембач Людмила Валентинівна Чехун Василь Федорович Швець Юлія Вікторівна popup.nrat_date 2020-04-02 Close