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Information × Registration Number 0213U004957, 0113U002611 , R & D reports Title Enhancement of antineoplastic action of novel anticancer drugs: application of combined chemotherapy and improvement of drug delivery popup.stage_title Head Stoika Rostyslav Stepanovych, Registration Date 13-01-2014 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 Structure-functional properties which determine anticancer activity of angucycline antibiotics of landomycin family and their unique ability to overcome acquired resistance of tumor cells to chemotherapy have been studied. It is shown that carbohydrate chain length and the presence of the hydroxyl group in 11 position of the aglycone are the key factors that determine the antitumor activity of landomycins. In particular, the loss of one carbohydrate residue reduces the anti-neoplastic activity of landomycins and their ability to produce reactive oxygen species by 60 % and the elimination of the C11 -OH group leads to further reduction of these values by 30 %. This directly affects the ability of these antibiotics to produce hydrogen peroxide in the mitochondria of malignant cells and to kill drug-resistant tumor cells. These results indicate on significant prospects of the most active members of landomycin family, in particular landomycin A, in the treatment of drug-resistant tumors. The results of this study are published in four thesis in the conference proceedings. Product Description popup.authors Панчук Ростислав Русланович popup.nrat_date 2020-04-02 Close