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Information × Registration Number 0213U004958, 0113U006249 , R & D reports Title Molecular design, synthesis and mechanism of biological activity of novel compounds on basis of 4-thiazolidone derivatives popup.stage_title Head Panchuk Rostyslav Ruslanovych, Registration Date 13-01-2014 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 It is shown that combination of the two side groups with different biological activity in one molecule of 4-thiazolidones led to a combination of molecular pathways of apoptosis induction by these active groups. These hybrid molecules not only exhibit significantly higher antineoplastic effect than their predecessors, but also lead to much faster induction of apoptosis in target cells. Synthetic 4 thiazolidone derivative Les-3661 was also shown to possess antitumor activity in vivo in two models of myeloid tumors - murine NK/Ly lymphoma and L1210 leukemia, leading to 1,6-2,5-fold increase of survival of tumor-bearing animals depending on the tumor model. These data indicate on a high promise of future clinical studies of this drug in experimental animals. On basis of obtained results a patent application has been submitted to Ukrainian patent office, and three abstracts were published in conference proceedings. Product Description popup.authors Панчук Ростислав Русланович popup.nrat_date 2020-04-02 Close