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Information × Registration Number 0213U005153, 0108U001804 , R & D reports Title Immunological features of opportunictic infection in HIV-infected patients receiving highly active antiretroviral therapy popup.stage_title Head Myroshnychenko Valentyn Pavlovych, Registration Date 22-03-2013 Organization State Institute "Zaporizhzhia Medical Academy of Postgraduate Education of Ministry of Health of Ukraine" popup.description2 102 patients with HIV-infection are surveyed, the assessment of immunological efficacy and surviving of patients is made at carrying out highly active antiretroviral therapy (HAART) throughout 3 years of supervision. At 58 patients it is made studying of indexes of specific and not specific immunity. It is shown that HIV-infection progressing is accompanied by reduction of absolute number of CD 3-lymphocytes, absolute and relative number of CD 4-lymphocytes and immunoreactivity index. Patients with HIV-infection, irrespective of CD 4-lymphocytes level, are increased the level of circulating immune complexes(with 5,8 to 13,6-15,9). With a significant immunodeficiency (the quantity of CD 4-lymphocytes <200 mkl-1) the functional-metabolic status of phagocytes and their bactericidal activity decline against increase of activity of system of a complement. Against HAART at a HIV-infected statistically significantly the absolute quantity of CD 4-lymphocyte (on 57 %), relative quantity CD 4-lymphocytes (on 50 %) and an immunoreactivity index (in 2 times) are raised after 24 weeks an initiation of treatment. The cumulative surviving of patients with a HIV-infection at carrying out HAART for three years of supervision compounds 87 %. Quantity CD4-lymphocyte less than 100 mkl-1 before beginning HAART it is necessary to consider as unfavorable predictor of surviving among patients with a HIV-infection. Dynamics of increase of level of average volume of erythrocytes on HAART can be used, as indirect objective criterion of adherence of the patient to treatment. Product Description popup.authors Живиця Дмитро Георгійович Живиця Людмила Василівна Лимар Сергій Костянтинович Пономаренко Галина Фролівна popup.nrat_date 2020-04-02 Close