Search academic texts

Information × Registration Number 0213U005567, 0109U007088 , R & D reports Title The investigation of the albumin-calcium complex as potential markers of oncology pathology popup.stage_title Head Sidorenko Michail Vasyl'ovych, Registration Date 17-07-2013 Organization Department of Biotechnical Problems of Diagnostics, Institute of Problems of Cryobiology and Cryomedicine of NAS of Ukraine popup.description2 Report on R & D 115 p., 31 fig., 27 tab. 4 applications 42 sources. Object of study: whole blood fibroadenomatoz women with breast cancer and breast cancer, human serum albumin (LSA). Purpose: The success of treatment of precancerous and malignant diseases is largely determined by the stage of the disease, which was diagnosed. Research "markers" of tumor growth at present not allow to draw on the results of tests as a marker for highly specific and essential for early diagnosis, especially for screening. Also recomended for use methods quite expensive. Thus, the problem of developing an affordable method of diagnosis BM at an early stage of the pathological process or implied, are detected by screening is important. Research Objectives for 2008-2012 was to establish reliable clinical and spectroscopic comparisons, in identification signs spectra of blood samples characteristically related to clinically diagnosed. It is shown that the spectral properties of thin films of dried blood and blood serum in the range 1700-1600 cm-1 adequately related to the state of the object - the source of the sample. Reliably established differences modification of the spectral characteristics of Ca2 + ions for the cases of apparently healthy women, women who suffer from fibroadenomatoz breast cancer and breast cancer. Revealed characteristic spectral properties of blood proteins in oncogenesis (in experiment and clinic). The effect of CaCl2 and other hygroscopic substances on the water content of the dried smears in isolation from the environment using infrared spectroscopic analysis. Investigated by absorption spectroscopy in the range 1700-1600сm-1 spectral characteristics of thin films of albumin people (in the experiment) and blood cancer patients to develop a new approach to the diagnosis of cancer marker. Methods and apparatus: IR spectroscopy, biochemical methods. Spectrometry performed on a spectrophotometer "Specord M-80". Results and novelty: It is shown that infrared spectroscopy in the range of range of 170-1600сm-1mozhe be used for early detection of cancer. Developed, validated and proposed to use the original algorithm and program automated processing of spectral data. Substantiates the position that the study of the spectral characteristics of blood samples has a "marker" and differential-diagnostic stress in carcinogenesis. Keywords: spectroscopy of blood, breast cancer, breast fibroadenomatoz, albumin, calcium. Product Description popup.authors Бурлака Дмитро Петрович Корицька Лідія Миколаївна Левченко Олег Євгенович Пелєвін Сергій В"ячеславович Першко Наталя Юріївна Пономарьов Ігор Олегович popup.nrat_date 2020-04-02 Close