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Information × Registration Number 0213U005571, 0113U003656 , R & D reports Title The investigation of expresion of marker proteins epithelial stem cells and progenitor cells in oral squamous cell carcinoma. popup.stage_title Head Sydorenko Mychail V., Registration Date 17-07-2013 Organization Department of Biotechnical Problems of Diagnostics, Institute of Problems of Cryobiology and Cryomedicine of NAS of Ukraine popup.description2 Abstract.Object of study: mucosal biopsy of the tumor and the distance from the existing tumors taken before treatment in 10 patients with squamous cell carcinoma of the oral cavity (10 tumor biopsies and 9 mucosal biopsies at a distance from the tumor) who were treated at the Clinical Research Division of the head and neck National Cancer Institute and mucosal biopsies 5, the control group (material Bureau of Forensic Medical Examination). Objective: To investigate the expression of the cell surface glycoprotein CD44, a marker that is common phenotype of stem cells and cancer stem cells, mucosal epithelium in the distance from the existing tumors and squamous cell carcinoma of the oral cavity and to compare the expression of marker proteins of epithelial stem cells and progenitor cells p63, CK5 / 14. Methods: a histological, immunohistochemical, immunohistochemical, monoclonal technology (Monoclonal Mouse Anti-Human CD44, Phagocytic Glicoprotein-1, clone DF1485, P63 antigen, clone 4A4, antigen to two cytokeratins SK5/14, clone LL002 and visualization system, "Dako Cytomation "Denmark). In the study of the expression of CD44 cell surface glycoprotein in mucosal epithelium away from established tumors and squamous cell carcinoma of the oral cavity is shown part of cells ekspresiruyuschih CD44, a marker of epithelial stem cells and is involved in cell adhesion and migration in the formation of a transformed phenotype in the biology of squamous oral cancer. Keywords: the epithelium of the oral mucosa, the transformed phenotype, squamous cell carcinoma, epithelial stem cells, progenitor cells, cancer stem cell markers CD44, h63, CK5/14, biomarkers p53, Ki-67, Bcl-2. Product Description popup.authors Кірєєва Світлана Сергіївна Сидоренко Михайло Васильвич Юрченко Наталя Петрівна popup.nrat_date 2020-04-02 Close