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Information × Registration Number 0213U005586, 0107U004082 , R & D reports Title Features, physiological and pathophysiological role of TRP ion channels family. popup.stage_title Head Shuba Yaroslav M., Доктор біологічних наук Registration Date 23-07-2013 Organization International center of molecular physiology popup.description2 The work has been devoted to the study of functional characteristics of cold / menthol-sensitive TRPM8 channel in rats and mice and study of sex, hormone-related differences in their electrophysiological properties. For the first time using electrophysiological approaches (patch-clamp whole cell) has been demonstrated that under normal TRPM8 channel is expressed in the apical plasma membrane prostate epithelial cells of rats. It is concluded that the differences observed in the behavior of males and females in innocuous cold temperatures, as well as functional properties of TRPM8 cold receptors through differential regulation of TRPM8 channel, independent of sex steroid hormones, testosterone and / or 17 beta-estradiol. In the study of malignant-transformed prostate cancer cells caused by excessive proliferation, it was shown that this is accompanied by reduced ability to apoptosis of the loss of the normal control of these two processes. In this case, calcium ions play a central role and act as the primary signaling agent. Disclosure of the basic molecular mechanisms involved in the functioning of specific cellular responses of Ca-binding proteins may help in developing new strategies in the treatment of prostate cancer. Product Description popup.authors Болдирєв О.І. Кондрацький А.П Любанова О.П. Носаль О.М Падурару О.М. popup.nrat_date 2020-04-02 Close