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Information × Registration Number 0213U005588, 0109U004188 , R & D reports Title The effects of polypeptides and small molecules, constructed on the basis of pharmacophore models of these peptides, on electrophysiological characteristics of central and peripheral neurones. popup.stage_title Head Krishtal Oleg O., Доктор біологічних наук Registration Date 23-07-2013 Organization International center of molecular physiology popup.description2 It was found that Big dynorphin (BigDyn) - endogenous opioid peptides in the micromolar concentration causes transient increase in conductance across the membrane of cells. Nonspecific opioid receptor antagonist nalakson showed no effect on BigDyn-induced changes in the conductivity of the membrane, indicating that opioid receptors are not mediated nature of the induced changes. At the same time, donorfiny A and B which are structural components BigDyn (at a concentration of 1 mM / L) did not show the ability to cause a change in conductivity. Thus, in addition to the canonical opioid receptor mediated mechanisms are responsible for BigDyn alternative signaling pathway which is based on the direct interaction of opioid neuropeptides with the plasma membrane. Product Description popup.authors Волкова Т. М. Карбовський В.І. Максимюк О. П. Хмиз В. В. Чіжмаков І. В. popup.nrat_date 2020-04-02 Close
R & D report
The effects of polypeptides and small molecules, constructed on the basis of pharmacophore models of these peptides, on electrophysiological characteristics of central and peripheral neurones.
Head: Krishtal Oleg O.. The effects of polypeptides and small molecules, constructed on the basis of pharmacophore models of these peptides, on electrophysiological characteristics of central and peripheral neurones.. (popup.stage: ). International center of molecular physiology. № 0213U005588
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Updated: 2026-03-26


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