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Information × Registration Number 0213U005805, 0111U008364 , R & D reports Title Regulation of excitability of neurons in mammalian peptide molecules of endogenous and exogenous origin popup.stage_title Head Kryshtal Oleg О., Доктор біологічних наук Registration Date 25-07-2013 Organization International center of molecular physiology popup.description2 The ability of positively charged endogenous peptides to alter the conductivity of plasma membrane of cells was studied using standard path-clamp technique in whole-cell configuration. It was found that Bіg Dyn at micromolar concentrations can cause stochastic transien fluctuations of the cellular membrane conductivity of the membrane. Submicromolar concentrations of Dyn A caused similar changes in conductivity as well as large fragment of dynorphin Bіg Dyn (6-26), but not Dyn B. The action of Bіg Dyn was compared with well-known cell-penetrating peptide Arg9. Bіg Dyn-induced fluctuations in the conductivity was dependent on extracellular concentration of calcium and magnesium. An estimate of the pore diameter were made in assumption that Bіg Dyn forms cylinder shaped ion-conducting channel in the membrane. Product Description popup.authors Волкова Т.М. Максимюк О.П. Хмиз В.В. Чіжмаков І.В. popup.nrat_date 2020-04-02 Close